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$advinst = New-Object -ComObject AdvancedInstaller
$project = $advinst.LoadProject("D:\PS support\sample.aip")

$project.DigitalSignature.EnableSigning() = 1
$project.Save()

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$project.DigitalSignature.SetUseFileFromDisk("D:\mycertificate.pfx")

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$advinst = New-Object -ComObject AdvancedInstaller
$project = $advinst.LoadProject("D:\sample.aip")

$CertificatesList = $project.DigitalSignature.Certificates

foreach ($element in $CertificatesList) {
  if (($element.Thumbprint -eq "8c5a55d94c9d4d6f8b0e8f4644768f00bf65dd2c") -and ($element.Store -eq "User\MY"))
  {
  $certificate = $element

  $certificate
  }
}

$project.DigitalSignature.SetUseFromPersonalCertificate($certificate)
$project.Save()